Isabelle De Plaen, MD
isabelledp@northwestern.edu
2300 Children's Plaza - Box #45
Room C421L
Chicago, IL 60614
Phone: (773) 755-6379
| Education |
|
|
| Year |
Degree |
Institution |
| 1998 |
Neonatology Fellowship |
Northwestern University Medical School, Chicago, IL |
| 1995 |
Pediatric Residency |
Universite Catholique de Louvain, Brussels, Belgium |
| 1994 |
Pediatric Residency |
California Pacific Medical Center, San Francisco, CA |
| 1989 |
M.D. |
Universite Catholique de Louvain, Brussels, Belgium |
| 1985 |
Candidatures en Sciences Medicales |
Universite Catholique de Louvain, Brussels, Belgium |
Lab Affiliations
De Plaen Lab
Recent Publications
De Plaen I.G., Liu SXL, Tian R, Neequaye I., May M., Han XB, Hsueh W, Jilling T, Lu J, Caplan MS. (April, 2007). Inhibition of NF-kB ameliorates bowel injury and prolongs survival in a neonatal rat model of necrotizing enterocolitis. Pediatric Research : 2007 Apr 5; [Epub ahead of print] .
Hsueh W, De Plaen IG, Caplan MS, Qu XW, Tan X-D, and Gonzalez Crussi F (2007). Neonatal necrotizing enterocolitis: Clinical aspects, experimental models and pathogenesis. World Journal of Pediatrics : 3 (1) (2007) 17-29.
De Plaen IG, Han XB, Liu X, Hsueh W, Ghosh S and May MJ. (June, 2006). Lipopolysaccharide induces CXCL2/ macrophage-inflamatory protein-2 gene expression in enterocytes via nuclear factor-kB activation: Independence from endogenous tumor necrosis factor-a and platelet-activating factor. Immunology: 118 (2) (2006) 153-163.
Qu XW, Thaete LG, Rozenfeld RA, Zhu Y, De Plaen IG, Caplan MS and Hsueh W. (May, 2005). Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: role of neuronal nitric oxide synthase. Critical Care Medicine: 33 (5) (2005) 1050-6.
Han XB, Liu X, Hsueh W and De Plaen IG (December, 2004). Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor. Am J Physiol Gastrointest Liver Physiol.: 281 (2004) 1220-1226.
Hsueh W, Caplan MS, Qu XW, Tan X-D, De Plaen IG, and Gonzalez Crussi F (January, 2003). Neonatal necrotizing enterocolitis: Clinical considerations and pathogenetic concepts . Pediatr Dev Pathol: 6-23.
De Plaen IG, Qu XW, Wang H, Tan X-D, Wang L, Han XB, Rozenfeld RA and Hsueh W (August, 2002). Endotoxin activates Nuclear Factor-KB and increases IKBalpha and IKBbeta turnover in enterocytes: Independence of platelet-activating factor. Immunology: 577-83.
Rozenfeld RA, Liu X., Deplaen I., and Hsueh W (October, 2001). Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. Am. J. Physiol.: 957-63.
Wang H, Qu X, De Plaen IG and Hsueh W. (July, 2001). Platelet-Activating Factor and endotoxin activate CCAAT/enhancer binding protein in rat small intestine. Brit J Pharmacol: 713-21.
Hummel M, Zhang J, Yan S, DePlaen I, Golia P, Thomas G, Varghese T, Li Z, Kaufman DB, Fryer JP, Leventhal J, Stuart FP, and Abecassis MI. (May, 2001). Allogeneic transplantation induces expression of cytomegalovirus immediate-early genes in vivo: a model for reactivation from latency. J Virol: 4814-22.
Qu, X.-W., Wang, H., De Plaen, I., Hsueh, W. (February, 2001). Neuronal nitric oxide synthase regulates the expression of inducible NOS in rat small intestine via modulation of nuclear factor kappa B. . FASEB J.: 439-46.
Chen YH, Lu Y, De Plaen IG, Wang LY and Tan XD (August, 2000). Transcription factor NF-KB signals anti-anoikic function of Trefoil Factor 3 on intestinal epithelial cells. BBRC: 576-82.
De Plaen IG, Tan X-D, Chang H, Wang L, Wang L, Remick DG, Hsueh W: (January, 2000). Lipopolysaccharide activates Nuclear Factor-KB in rat intestine: Role of endogenous platelet-activating factor and tumor necrosis factor. Brit J Pharmacol, : 307-314.
De Plaen IG, Tan X-D, Chang H, Qu X-W, Liu Q-P, Hsueh W (June, 1998). NF-KB in rat intestine is composed of p50 homodimers and is activated by platelet-activating factor. Biochim Biophys Acta,: 185-192.
De Plaen IG (April, 1997). Index of suspicion - case 2. Pediatric in Review : 137-139.
Websites
Necrotizing enterocolitis
Biography
Dr De Plaen’s research focuses on the developmental aspects of the inflammatory mechanisms contributing to necrotizing enterocolitis, a devastating disease of the premature infant, causing sudden bowel inflammation and necrosis. Her special interest is in the regulation of pro-inflammatory cytokines and its regulation by transcription factors. She also works as a Neonatologist at Children's Memorial Hospital and Prentice Woman’s Hospital.
Last Updated: May 31 2007 12:51PM