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Alexandre attended the University of São Paulo in Brazil where he got a bachelor’s degree in Chemistry. During this time, he spent four years working in a laboratory that studied bioinorganic chemistry. There he worked on synthesizing and studying the interactions of dimetalic units of ruthenium and copper compounds and their potential roles as anti-inflammatory drugs. As a graduate student he performed research on the DNA amplification of the polytene chromosomes of the fly, Rhynchosciara americana. He focused on heat shock family genes, involved in the folding of proteins synthesized during a period concomitant with DNA amplification.
Currently, Alexandre is a post doctoral associate in Dr. Soares' lab where he is working on integrated analysis of the genome, epigenome, and transcriptome in normal and cancer cells. Ultimately, his work will generate a genome landscape of hypo- and hyper-methylated regions. This will be obtained using DNA extracted from normal and tumor tissues. The comparison of both landscapes will also identify regions of chromosomal rearrangements including deletions, duplications, and inversions. |