Profile

 

Xin Liu, MD, PhD 

  

Assistant Professor, Child Health Research 

xnliu@childrensmemorial.org 

1731 N Marcey St
Room 413
Chicago, IL 60637
Phone: (312) 573-7751
Fax: (312) 573-7825

 

 

Education 

   
  

Year 

Degree 

Institution  

 

2002

PhD 

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 

 

1993

MD 

Shandong Medical University, China

 

 

Work Experience 

 
  

Period 

Description 

Organization  

 

2007 - Present

Assistant Professor

Mary Ann and J. Milburn Smith Child Health Research Program, Children's Memorial Hospital/Research Center; and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago.
 

 

2004 - 2006 

Postdoctoral fellow

 University of California at San Francisco

 

2002 - 2003 

Postdoctoral fellow

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

 

1999 - 2002 

Research Assistant

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 

 

1993 - 1995

General Physician

Beijing Sanatorium Hospital, Beijing, China

 

 

Research Interests 

 

Genetic Epidemiology
Statistical Genetics
Preterm Birth
Food Allergy
Allergic Sensitization
Cancer 

 

 

Recent Publications 

 

Liu X, Wang GY, Hong XM, Tsai HJ, Liu R, Zhang SC, Wang HJ, Pearson C, Ortiz K, Wang D, Hirsch E, Zuckerman B, Wang XB. Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a U.S. urban black population. Human Genetics 2011 Aug 17. [Epub ahead of print]. 

Tsai HJ, Hong XM, Chen JB,  Liu X, Pearson C, Ortiz K, Hirsch E, Heffner L, Weeks DE, Zuckerman B, Wang XB. The role of African ancestry and gene-environment interactions in predicting preterm birth. Obstetrics & Gynecology (in press). 

Liu X, Cheng I, Plummer SJ, Suarez B, Casey G, Catalona WJ, Witte JS. Fine mapping of prostate cancer aggressiveness loci on chromosome 7q22-35. The Prostate 2011;71(7): 682-685.   

Zhang S, Liu X, Kim JS, Ouyang F, Wang B, Li Z, Tang G, Liu X, Yang J, Xu X, Wang X. Association between short sleep duration and the risk of sensitization to food and aero allergens in Rural Chinese Adolescents. Clinical and Experimental Allergy 2011;41(4):547-55. (Co-first author) 

Kumar R, Tsai HJ, Hong XM, Liu X, Wang GY, Pearson C, Ortiz K, Fu M, Pongracic JA, Bauchner H, Wang XB. Race, Ancestry and Development of Food Allergen Sensitization in Early Childhood. Pediatrics 2011 Sep 2. [Epub ahead of print] 

Liu X, Wang GY, Hong XM, Wang D, Tsai HJ, Zhang SC, Arguelles L, Kumar R, Wang HJ, Liu R, Zhou Y, Pearson C, Ortiz K, Schleimer R, Holt P, Pongracic J, Price HE, Langman C, Wang XB. Gene-Vitamin D interactions on food sensitization: a prospective birth cohort study. Allergy 2011 Aug 5. doi: 10.1111/j.1398-9995.2011.02681.x. [Epub ahead of print].   

Liu R, Liu X, Arguelles L, Patwari, PP, Zee PC, Chervin RD, Ouyang F, Christoffel KK, Zhang SC, Wang GY, Xu X, Wang XB. A population-based twin study on sleep duration and body composition. Obesity 2011 Aug 25. doi: 10.1038/oby.2011.274. [Epub ahead of print]. 

Hong X, Arguelles LM, Liu X, Tsai H, Hsu Y, Wang B, Zhang S, Li Z, Tang G, Liu X, Yang J, Wang L, Xu X, Langman C, Wang X.  Percent fat mass is inversely associated with bone mass and hip geometry in Rural Chinese Adolescents. Journal of Bone and Mineral Research 2010; 29;25(7):1544-1554.  

Zhang SC, Liu X, Necheles J, Tsai HJ, Wang GY, Wang BY, Xing H, Li Z, Liu X, Zang R, Xu X, Wang XB. Genetic and environmental influences on serum lipid tracking: a population-based, longitudinal Chinese twin study. Pediatric Research 2010; 68(4):316-312. 

Wang GY, Liu X, Christoffel KK, Zhang SC, Wang BY, Liu R, Li Z, Liu X, Rang G, Xing H, Brickman WJ, Zimmerman D, Xu X, Wang XB. Prediabetes is not all about obesity: association between plasma leptin and prediabetes in lean rural Chinese adults. European Journal of Endocrinology 2010; 163(2):243-249. 

Hong X, Tsai HJ, Liu X, Arguelles L, Kumar R, Wang GY, Kuptsova-Clarkson N, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Pongracic JA, Schleimer R, Holt PG, Bauchner H, Wang XB. Does Genetic Regulation of IgE Begin In-Utero? Evidence from TH1/TH2 Gene Polymorphisms and Cord Blood Total IgE. The Journal of Allergy and Clinical Immunology 2010;126(5):1059-1067. (Co-first author)     

Yu Y, Tsai HJ, Liu X, Zhang  S, Pearson C, Ortiz K, Zuckerman B, Bauchner H,  Xu X, Wang X. The joint association between F5 gene polymorphisms and maternal smoking during pregnancy on preterm delivery.  Human Genetics  2009;124: 659-68. PMCID: PMC Journal-In Process 

Ross PL, Cheng I, Liu X, Cicek MS, Carroll PR, Casey G, Witte JS.  Caboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer. BMC Cancer 2009 Feb 26; 9:69. PMCID: PMC2657151 

Ouyang F,  Kumar R, Pongracic J, Story RE, Liu X, Wang B, Xing H, Liu X, Li Z, Zhang W, Fang Y, Zhang S, Xu X, Wang X. Adiposity, serum lipid levels, and allergic sensitization in Chinese men and women. Journal of Allergy & Clinical Immunology 2009;123(4):940-8. PMCID: PMC2697621 

Tsai HJ, Kumar R, Pongracic J, Liu  X, Story R, Yu Y, Deanna C, Costello J, Schroeder A, Fang Y, O'Gorman M, Wang X. Familial aggregation of food allergy and sensitization to food allergens: A family-based study.  Clinical and Experimental Allergy 2009 Jan;39(1):101-9. PMCID: PMC2729087 

Mestan K, Yu Y, Thorsen P, Skogstrand K, Matoba N, Liu X, Kumar R, Hougaard DM, Bauchner H, Wang X. Cord blood biomarkers of the fetal inflammatory response. Journal of Maternal-Fetal & Neonatal Medicine 2009; 22: 379-387.   

 Liu X, Zhang SC, Tsai HJ, Hong XM, Wang BY, Fang YP, Liu X, Pongracic J, Wang X. Genetic and Environmental Contributions to Allergen Sensitization in a Chinese Twin Study.  Clinical and Experimental Allergy 2009 Jul;39(7):991-8. PMCID: PMC2756049  

Arguelles LM, Langman CB, Ariza AJ, Ali FN, Dilley K, Price H, Liu X, Zhang S, Hong X, Wang B, Xing H, Li Z,  Liu X, Zhang W, Xu X, Wang X.  Heritability and environmental factors affecting vitamin D status in rural Chinese adolescent Twins.  Journal of Clinical Endocrinology and Metabolism 2009;(94)9:3273-81. PMCID: PMC2741721 

Zhang S, Liu X, Yu Y, Hong X, Christoffel KK, Wang B, Tsai HJ, Li Z, Liu X, Tang G, Xing H, Brickman WJ, Zimmerman D, Xu X, Wang X. Genetic and Environmental Contributions to Phenotypic Components of Metabolic Syndrome: A Population-based Twin Study. Obesity 2009;(17)8:1581-87. PMCID: PMC Journal-In Process (Co-first author) 

Zhang S, Liu X, Brickman WJ, Christoffel KK, Zimmerman D, Tsai HJ, Wang G, Wang B, Li Z, Tang G, Liu X, Yang J, Xu X, Wang X. Association of Plasma Leptin Concentrations with Adiposity Measurements in Rural Chinese Adolescents. Journal of Clinical Endocrinology and Metabolism 2009; (94)9:3497-504. PMCID: PMC2741718    

Hong X, Tsai H, Liu X, Li Z, Liu X, Tang G, Xing H, Yang J,  Wang B, Feng Y, Xu Xin, Xu Xiping, Wang X.  A Large-scale genome-wide linkage analysis to map loci linked to stature in Chinese population.  Journal of Clinical Endocrinology & Metabolism  2008; 93: 4511-8. PMCID:PMC2582574 

Kim JS, Ouyang F, Pongracic JA, Fang Y, Wang B, Liu X, Xing H, Caruso D, Liu X, Zhang S, Xu X, Wang X.  Dissociation between the prevalence of atopy and allergic disease in rural China among children and adults. Journal of Allergy & Clinical Immunology 2008; 122: 929-935. PMCID: PMC2747487 

Cheng I, Jorgenson E, Plummer SJ, Liu X, Rybick BA, Casey G, Witte JS (2008). 8q24 and prostate cancer: associated with advanced disease and meta-analysis. European Journal of Human Genetics, 2008; 16: 496-505.

Tsai H, Liu X, Mestan K, Yu Y, Zhang S, Pearson C, Ortiz K, Zuckerman B, Bauchner H, Cerda S, Stubblefield P, Xu X, Wang X (2008). Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: New insights on GxE interactions and pathogenic pathways. Human Genetics, 2008;123: 359-69.

Jorgenson E, Deitcher SR, Cicek M, Liu X, Plummer S, Casey G, Witte JS (2007). Plasminogen activator inhibitor type-1 (PAI-1) polymorphism 4G/5G is associated with prostate cancer among men with a positive family history. Prostate, 2007; 67: 172-77.

Chang YP, Liu X, Kim J, Ikeda MA, Layton M, Weder A, Cooper R, Kardia S, Rao DC, Hunt S, Luke A, Boerwinkle E, Chakravarti A (2007). Multiple Essential Hypertension Susceptibility Genes On Chromosome 1q. AM J Hum Genet, 2007; 80: 253-64.

Liu X, Cicek MS, Plummer SJ, Jorgenson E, Casey G, Witte JS (2007). Association of Testis-Derived Transcript (TES) gene variants and prostate cancer risk. The Journal of Urology, 2007;177: 894-8.

Liu X, Schumacher FR, Plummer SJ, Jorgenson E, Casey G, Witte JS (2007). Trans Fatty Acid Intake and Increased Risk of Advanced Prostate Cancer: Modification by RNASEL R462Q Variant. Carcinogenesis, 2007;28: 1232-6.

Cheng I, Liu X, Plummer SJ, Krumroy LM, Casey G, Witte JS (2007). COX2 Genetic Variation, NSAIDs, and Advanced Prostate Cancer Risk. British J of Cancer, 2007; 20; 97: 557-61.

Casey G, Neville PJ, Liu X, Plummer SJ, Cicek MS, Krumroy LM, Curran AP, McGreevy MR, (2006). Podocalyxin variants and risk of prostate cancer and tumor aggressiveness. Human Molecular Genetics, 2006;15: 735-741.

Nock NL, Liu X, Cicek MS, Li L, Macarie F, Rybick BA, Plummer SJ, Maclennan GT, Casey G, Witte JS (2006). Polymorphisms in polycyclic aromatic hydrocarbon metabolism and conjugation genes, interactions with smoking and prostate cancer risk. Cancer Epidemiology, Biomarkers & Prevention, 2006;15: 756-61.

Nock NL, Cicek MS, Li L, Liu X, Rybick BA, Moreira A, Plummer SJ, Casey G, Witte JS (2006). Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk. Carcinogenesis, 2006;27: 1842-48.

Liu X, Plummer SJ, Nock NL, Casey G, Witte JS (2006). Nonsteroidal Anti-inflammatory Drugs and Decreased Risk of Advanced Prostate Cancer: Modification by Lymphotoxin Alpha. American Journal of Epidemiology, 2006;164: 984-89.

Cicek MS, Liu X, Schumacher FR, Casey G, Witte JS (2006). Vitamin D receptor genotypes/haplotypes and prostate cancer risk. Cancer Epidemiology, Biomarkers & Prevention,,2006;15: 2549-52.

Cicek MS, Liu X, Casey G, Witte JS (2005). Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11α in prostate cancer risk and aggressiveness. Cancer Epidemiology, Biomarkers & Prevention, 2005; 14: 2173-2177. (Co first-author).

Liu X, Jorgenson E, Witte JS (2005). Hierarchical modeling in association studies of multiple phenotypes. BMC Genetics, 2005;6(S1): S104.

Liu X, Rybicki BA, Casey G, Witte JS (2005). Relationship between body size and prostate cancer in a sibling-based case-control study. The Journal of Urology, 2005;174: 2169-73.

Jorgenson E, Liu X, Witte JS (2005). Case-Control Analyses: Geneopardy! . Genetic Epidemiology, : S86-S90.

Liu X, Beaty TH, Deindl P, Huang SK, Lau S, Sommerfeld C, Fallin D, Kao WH, Wahn U, Nickel R (2004). Association between specific serum IgE response and 6 variants within genes IL4, IL13 and IL4R in German Children: the German Multicenter Atopy Study (MAS). The Journal of Allergy and Clinical Immunology, 2004; 113: 489-95.

Liu X, Fallin MD, Kao WH (2004). Genetic dissection methods: designs used for tests of gene-environment interaction. Current Opinion in Genetics & Development, 2004; 14: 241-45.

Wang QF, Liu X, O’Connell J, Peng Z, Krauss RM, Rainwater DL, VandeBerg JL, Rubin EM,, Cheng JF, Pennacchio LA (2004). Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons. Human Molecular Genetics, 2004; 13: 1049-56.

Liu X, Beaty TH, Deindl P, Huang SK, Lau S, Sommerfeld C, Fallin D, Kao WH, Wahn U, Nickel R (2003). Association between total serum IgE levels and the six potentially functional variants within genes IL4, IL13 and IL4R in German Children: the German Multicenter Atopy Study (MAS). The Journal of Allergy and Clinical Immunology, 2003; 112: 382-388. Editor’s Choice.

Huang SK, Mathias RA, Ehrlich E, Plunkett B, Liu X, Cutting GR, Wang XJ, Li XD, Togias A, Barnes KC, Malveaux F, Rich S, Mellen B, Lange E, Beaty TH and the CSGA (2003). Evidence for asthma susceptibility genes on Chromosome 11 in an African American population. Human Genetics, 2003; 113: 71-5.

Liu X, Nickel R, Beyer K, Wahn U, Ehrlich E, Freidhoff LR, Björkstén B, Beaty TH, Huang SK and the MAS-Study Group (2000). An IL13 coding region variant is associated with high total serum IgE level and atopic dermatitis in German Multicenter Atopy Study (MAS-90). The Journal of Allergy and Clinical Immunology, 2000;106: 167-170.