| |
Strizzi L, Hadry KM, Seftor EA, Margaryan NV, Kirschmann DA, Kirsammer GT, Bailey CM, Kasemeier-Kulesa JC, Kulesa PM, Seftor REB and Hendrix MJC (2011). Lessons from embryogenesis. In: Melanoma Development – Molecular Biology, Genetics and Clinical Applications, edited by A Basserhoff, in press.
Lawrence, MG, Margaryan MV, Loessner D, Collins A, Kerr K, Turner M, Seftor EA, Stephens CR, Lai J, APC Biosource, Postovit L-M, Clements JA and Hendrix MJC (2011). Reactivation of embryonic Nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. The Prostate, in press.
Hardy KM, Kirschmann DA, Seftor EA, Margaryan NV, Postovit L-M, Strizzi L and Hendrix MJC (2010). Regulation of the embryonic morphogen Nodal by Notch4 facilitates the manifestation of the aggressive melanoma phenotype. Cancer Res, 70:10340-10350. (Cover Illustration and Highlighted)
Hamm CA, Stevens JW, Xie H, Vanin EF, Morcuende J, Abdulkawy H, Seftor EA, Sredni ST, Bischof J, Wang D, Malchenko S, Bonaldo MF, Casavant T, Hendrix MJC, Soares MB (2010). Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors. BMC Cancer, 10:471-86.
Malchenko S, Galat V, Seftor EA, Vanin EF, Costa FF, Seftor REB, Soares MB and Hendrix MJC (2010). Cancer Hallmarks in induced pluripotent cells: New insights. J Cell Physiol, 225:390-393. (Cover Illustration and Highlighted)
Hamm CA, Xie H, Costa FF, Vanin EF, Seftor EA, Sredni ST, Bischof J, Wang D, Bonaldo MF, Hendrix MJC, Soares MB (2009). Global demethylation of rat chondrosarcoma cells after treatment with 5-Aza-2’-deoxycytidine results in increased tumorigneicity. PLOSOne, 4:e8340.doi:10.1371.
Costa FF, Seftor EA, Bischof JM, Kirschmann DA, Strizzi L, Arndt K, Bonaldo MdF, Soares MB, Hendrix MJC. 2009. Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment. Epigenomics, 1:387-398.
Orgaz JL, Ladhani O, Hoek KS, Fernandez-Barral A, Seftor EA, Bernand A, Rodriguiez-Peralto JL, Hendrix MJC, Volpert OV and Jimenez B (2009). Loss of pigment epithelium=derived factor enables migration, invasion and metastatic spread of human melanoma. Oncogene, 28:4147-4161.
Strizzi L, Hardy KM, Seftor EA, Costa FF, Kirschmann DA, Seftor REB, Postovit LM and Hendrix MJC (2009). Development and cancer:At the crossroads of Nodal and Notch signaling. Cancer Research, 69:7131-7134 (Highlighted)
Strizzi L, Postovit L-M, Margaryan NV, Lipavsky A, Gadiot J, Blank C, Seftor REB, Seftor EA and Hendrix MJC (2009). Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention. Expert Rev Dermatol, 4:67-78.
Margaryan NV, Strizzi L, Abbott DE, Seftor EA, Sambasiva R, Hendrix MJC and Hess AR (2009). EphA2 as a promoter of melanoma tumorgenicity. Cancer Biology & Ther, 8:275-284.
Kasemeier-Kulesa JC, Teddy JM, Postovit LM, Seftor EA, Seftor REB, Hendrix MJC, Kulesa PM (2008). Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment . Dev Dynam (special issue,) 237:2657-2666 .
Strizzi L, Postovit LM, Margaryan NV, Seftor EA, Abbott DE, Seftor REB, Salomon DS and Hendrix MJC (2008). Emerging roles of nodal and cripto-1: From embryogenesis to breast cancer progression. Breast Disease (special issue), 29:91-103.
Postovit LM, Margaryan NV, Seftor EA, Kirschmann DA, Lipavsky A, Wheaton WW, Abbott DA, Seftor REB and Hendrix MJC (2008). Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci, 105: 4329–4334.
( Download Adobe Acrobat PDF )
Abbott DE, Bailey CM, Postovit LM, Seftor EA, Margaryan NV, Seftor REB and Hendrix MJC (2008). The epigenetic influence of tumor and embryonic microenvironments: How different are they? . Cancer Microenvironment, 1:13-21.
Postovit LM, Margaryan NV, Seftor EA and Hendrix MJC (2008). Role of nodal signaling and the microenvironment underlying melanoma plasticity. Pig Cell Melanoma Res, 21:348-357.
( Download Adobe Acrobat PDF )
Postovit LM, Seftor EA, Seftor REB and Hendrix MJC (2008). From local invasion to metastatic cancer: Involvement of distant sites through the lymphovascular system. USA: Humana Press.
Postovit LM, Margaryan NV, Seftor EA, Strizzi L, Seftor REB and Hendrix MJC (2008). Plasticity underlying multipotent tumor stem cells in Bagley RG and Teicher BA, Stem Cells and Cancer. USA: Humana Press.
Hendrix MJC, Luo J, Seftor EA, Sharma N, Heidger PM Jr, Cohen MB, Bhatty R, Chunthapong J, Seftor REB and Lubaroff DM (2007). Epithelial-mesenchymal interactions in prostatic tumor cell plasticity in RL Ablin and MD Mason, Cancer Metastasis – Biology and Treatment , 10:127-141. Netherlands:Kluwer Academic Publishers.
Postovit LM, Costa FF, Bischof JM, Seftor EA, Wen B, Seftor REB, Feinberg AP, Soares MB and Hendrix MJC (2007). The commonality of plasticity underlying multipotent tumor cells and embryonic stem cells. J Cell Biochem, 101:908-917.
( Download Adobe Acrobat PDF )
Hendrix MJC, Seftor EA, Seftor REB, Kasemeier-Kulesa J, Kulesa PM and Postovit LM (2007). Reprogramming metastatic tumor cells with embryonic microenvironments. . Nature Rev Cancer, 7:246-255. (Cover Illustration and Highlighted)
( Download Adobe Acrobat PDF )
Postovit LM, Seftor EA, Seftor REB and Hendrix MJC (2007). Targeting Nodal in malignant melanoma cells.. Expert Opinion Ther Targets, 11:497-505.
( Download Adobe Acrobat PDF )
Abbott DE, Postovit LM, Seftor EA, Margaryan NV, Seftor REB and Hendrix MJC (2007). Exploiting the convergence of embryonic and tumorigenic signaling pathways to develop new therapeutic targets. Stem Cell Rev, 3:68-78.
( Download Adobe Acrobat PDF )
Hess AR, Margaryan NV, Seftor EA and Hendrix MJC (2007). Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: role of the Eph receptors. Devel Dynam, 236:3283-96.
( Download Adobe Acrobat PDF )
Postovit LM, Seftor EA, Seftor REB and Hendrix MJC (August, 2006). Influence of the microenvironment on melanoma cell fate determination and phenotype. Cancer Research, 66: 7833-7836..
( Download Adobe Acrobat PDF )
Postovit LM*, Seftor EA*, Seftor REB and Hendrix MJC (*equal authorship). (2006). A 3-D Model to Study the Epigenetic Effects Induced by the Microenvironment of Human Embryonic Stem Cells. Stem Cells, 24:501-505.
( Download Adobe Acrobat PDF )
Seftor EA, Meltzer PS, Kirschmann DA, Margaryan NV, Nickoloff BJ, Seftor REB and Hendrix MJC (2006). The epigenetic reprogramming of poorly aggressive melanoma by a metastatic melanoma microenvironment: Biomechanical role of matrix deformability.. J Cell Mol Med,: 10:174-196.
( Download Adobe Acrobat PDF )
Norwood LE, Moss TJ, Margaryan NV, Cook SL, Wright L, Seftor EA, Hendrix MJ, Kirschmann DA, Wallrath LL (2006). A requirement for dimerization of HP1Hsalpha in suppression of breast cancer invasion. J Biol Chem, 281:18668-18676.
( Download Adobe Acrobat PDF )
Hess AR, Seftor EA, Gruman LM, Kinch MS, Seftor REB, and Hendrix MJC (2006). VE-cadherin regulates EphA2 by in aggressive melanoma cells through a novel signaling pathway: Implications for vasculogenic mimicry.. Cancer Biology & Therapy, 5:e1-e6 (Cover Illustration).
( Download Adobe Acrobat PDF )
Kulesa PM, Kasemeier-Kulesa JC, Teddy JM Margaryan NV, Seftor EA, Seftor REB and Hendrix MJC (2006). Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment. . Proceedings National Academy Sciences, 103:3752-3757.
( Download Adobe Acrobat PDF )
Rojas JD, Sennoune SR, Maiti D, Bakunts K, Reuveni M, Sanka SC, Martinez GM, Seftor EA, Meininger CJ, Wu G, Wesson DE, Hendrix MJC and Martinez-Zaguilan R (2006). Vacuolar type H+-ATPases at the plasma membrane regulate pH and cell migration in microvascular endothelial cells. J Physiol: Heart Circulation Physiology, 291(3):H1147-57.
Hendrix MJC, Seftor EA and Seftor REB (2006). Vasculogenic mimicry: Angiogenesis in Disguise? in Forough R, New Frontiers in Angiogenesis: 97-109. Springer, Dordrecht .
Bailey CM, Khalkhali-Ellis Z, Seftor, EA and Hendrix MJC (2006). The biological functions of maspin. J Cell Physiol. (Art Pardee special issue), 209:617-624.
( Download Adobe Acrobat PDF )
Lee, MJ, Seftor EA, Bonde G, Cornell R, Hendrix MJC (2005). The fate of human malignant melanoma cells transplanted into zebrafish embryos: Assessment of migra-tion and cell division in the absence of tumor formation.. Developmental Dynamics, 233:1560-1570.
( Download Adobe Acrobat PDF )
Hess AR, Postovit LM, Margaryan NV, Seftor EA, Schneider GB, Seftor REB, Nickoloff BJ and Hendrix MJC (2005). Focal adhesion kinase promotes aggressive melanoma phenotype. . Cancer Research, 65:9851-9860 (Highlighted).
Seftor EA, Brown K, Chin L, Kirschmann DA, Wheaton WW, Protopopov A, Feng B, Balagurunathan Y, Trent JM, Nickoloff BJ, Seftor REB and Hendrix MJC (2005). Epigenetic transformation of normal melanocytes by a metastatic melanoma microenvironment. . Cancer Research, 65:10164-10169 (Highlighted).
( Download Adobe Acrobat PDF )
Payne SL, Fogelgren B, Hess AR, Seftor EA, Wiley EL, Fong SFT, Csiszar K, Hendrix MJC and Kirschmann DA (2005). Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. . Cancer Research, 65:11429-11436.
( Download Adobe Acrobat PDF )
Seftor EA, Meltzer PS, Kirschmann DA, Margaryan NV, Seftor REB and Hendrix MJC (2005). The epigenetic influence of the tumor microenvironment on melanoma plasticity. in GG Meadows, Integration/Interaction of Oncogenic Growth: 47-63. Netherlands: Kluwer Academic Publishers.
Hendrix MJC, Seftor EA and Seftor REB (2005). The plasticity of melanoma cells and associated clinical implications in V Hearing and SPL Leong, Melanocytes to Melanoma: The progression to malignancy: 535-552. USA: Humana Press.
( Download Adobe Acrobat PDF )
Seftor REB, Seftor EA, Hess AR and Hendrix MJC (2004). The role of the vasculogenic phenotype and its associated extracellular matrix in tumor progression: Implications for immune surveillance. . Clinical & Applied Immunology Reviews, 3:263-276.
van der Schaft DWJ, Seftor REB, Seftor EA, Hess AR, Gruman LM, Kirschmann DA, Yokoyama Y, Griffioen AW and Hendrix MJC (2004). Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells. Journal of the National Cancer Institute, 96: 1473-1477.
( Download Adobe Acrobat PDF )
Sood AK, Fletcher MS, Coffin JE, Yang M, Seftor EA, Gruman LM, Gershenson DM and Hendrix MJC (2004). Functional roles of matrix metalloproteinases in ovarian tumor cell plasticity. Amer J Obstet Gyn, 190:899-909.
( Download Adobe Acrobat PDF )
Qin J-Z, Stennett L, Bacon P, Bodner B, Hendrix MJC, Seftor REB, Seftor EA, Margaryan NV, Pollock P, Curtis A, Trent JM, Bennett F,, Miele L and Nickoloff BJ (2004). p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.. Molecular Cancer Therapeutics, 3:895-902.
( Download Adobe Acrobat PDF )
Hendrix MJC, Seftor EA, Meltzer PS, Hess AR, Gruman LM, Nickoloff BJ, Miele L, Sheriff DD and Schatteman GC, Bourdon MA and Seftor REB (2004). The stem cell plasticity of aggressive melanoma tumor cells in ES Sell, Germinal Stem Cells: 27:297-306. USA: Humana Press .
Hendrix MJC, Seftor EA, Hess AR and Seftor REB (2003). The molecular plasticity of human melanoma cells. Oncogene, 22:3070-3075.
( Download Adobe Acrobat PDF )
Hendrix MJC, Seftor EA, Hess AR and Seftor REB (2003). Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma. Nature Reviews Cancer, 3:411-421.
( Download Adobe Acrobat PDF )
Hendrix MJC, Seftor EA, Kirschmann DA, Quaranta V and Seftor REB (2003). Remodeling the microenvironment by aggressive melanoma tumor cells. . Annals NY Academy of Science, 995:151-161.
Odero-Marah V, Khalkhali-Ellis Z, Seftor EA, Seftor REB and Hendrix MJC (2003). Maspin regulates cell motility through the RAC signaling pathway. Cancer Biology & Ther, 2:67-72.
( Download Adobe Acrobat PDF )
Hess AR, Seftor EA, Seftor REB and Hendrix MJC (2003). Phosphoinositide 3-kinase regulates membrane type-1 matrix metalloproteinase (MT1-MMP) and MMP-2 activity during melanoma cell vasculogenic mimcry. Cancer Research, 63:4757-4762.
( Download Adobe Acrobat PDF )
Ruf W, Seftor EA, Prtrovan R, Weiss RM, Gruman LM, Margaryan NV, Seftor REB, Miyagi Y and Hendrix MJC (2003). Differential role of tissue factor pathway inhibitors-1 and 2 (TFPI-1 and 2) in melanoma vasculogenic mimicry. Cancer Research, 63:5381-5389.
( Download Adobe Acrobat PDF )
Chunthapong J, Seftor EA, Khalkhali-Ellis Z, Seftor REB, Amir S, Lubaroff DM, Heidger PM Jr. and Hendrix MJC (2003). Dual roles of E-cadherin in prostate cancer invasion. J Cellular Biochemistry, 91:649-661.
( Download Adobe Acrobat PDF )
Seftor EA, Meltzer PS, Kirschmann DA, Pe’er J, Maniotis AJ, Trent JM, Folberg R and Hendrix MJC (2002). Molecular determinants of human uveal melanoma invasion and metastasis. Clinical Experimental Metastasis, 19:233-246.
( Download Adobe Acrobat PDF )
Hendrix MJC, Seftor REB, Seftor EA, Gruman LM, Lee LML, Nickoloff BJ, Miele L, Sheriff DD and Schatteman GC (2002). Transendothelial function of human metastatic melanoma cells: Role of the microenvironment in cell-fate determination. Cancer Research, 62:665-668 (Cover Illustration).
( Download Adobe Acrobat PDF )
Seftor EA, Meltzer PS, Kirschmann DA, Pe’er J, Maniotis AJ, Trent JM, Folberg R and Hendrix MJC (2002). Expression of multiple molecular phenotypes by aggressive melanoma tumor cells: Role of vasculogenic mimicry. Critical Reviews in Oncology/Hematology, 44:17-27.
( Download Adobe Acrobat PDF )
Seftor REB, Seftor EA, Kirschmann DA and Hendrix MJC (2002). Targeting the tumor microenvironment with chemically modified tetracyclines: Inhibition of laminin 5gamma2 chain promigratory fragments and vasculogenic mimicry. Molecular Cancer Therapeutics, 1:1173-1179.
( Download Adobe Acrobat PDF )
Seftor REB, Seftor EA, Gardner LMG, Bilban M, Koshikawa N, Trent J, Meltzer PS, Stetler-Stevenson WG, Quaranta V and Hendrix MJC (2001). Cooperative interactions of laminin 5 Gamma2, MMP-2 and MT1-MMP are required for mimicry of embryonic vasculo-genesis by aggressive melanoma. Cancer Research, 61:6322-6327 (Cover Illustration).
( Download Adobe Acrobat PDF )
Hendrix MJC, Seftor EA, Meltzer PM, Gardner LMG, Hess AR, Kirschmann DA, Schatteman GC and Seftor REB (2001). Expression and functional significance of VE-cadherin in aggressive melanoma cells: Role in Vasculogenic mimicry. Proceedings of the National Academy of Sciences, 98:8018-8023.
( Download Adobe Acrobat PDF )
Bittner M, Meltzer P, Chen Y, Jiang Y, Seftor E, Hendrix M, Radmacher, Simon R, Yakhini Z, Ben-Dor A, Dougherty E, Pollock P, Dietrich K, Alberts D, Sondak V, Hayward N and Trent J (2000). Molecular classification of cutaneous malignant melanoma by gene expression: Shifting from a continuous spectrum to distinct biologic entities. Nature, 406:536-540.
( Download Adobe Acrobat PDF )
|