CMRC Children's Memorial Research Center
Neuro Oncology

For information on the following Clinical Trials, please contact the
Hematology, Oncology and Stem Cell Transplantation Department
at 773-880-4562 during 8:30 AM to 5:00 PM Central Standard Time.

  Newly Diagnosed Brain Tumors  Investigator
  High-Grade Glioma and Brain Stem Glioma  
ACNS0222 A Phase II Study of Motexafin-Gadolinium and Involved Field Radiation Therapy for Intrinisic Pontine Glioma of Childhood Stewart Goldman, MD
PBTC-021 A Phase I Trial of Capecitabine Rapidly Disintegrating Tablets and Concomitant Radiation Therapy in Children with Newly Diagnosed Brainstem Gliomas and High Grade Gliomas Stewart Goldman, MD
     
  Medulloblastoma  
ACNS0331 A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy 18.00 Gy and Chemotherapy In Children with Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial Stewart Goldman, MD
ACNS0332 Efficacy of Carboplatin Administered Concomitantly with Radiation and Isotretinoin as a Pro-Apoptotic Agent in Other than Average Risk Medulloblastoma/PNET Patients Stewart Goldman, MD
ACNS0334 A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children < 36 months Old with Intensive Induction Chemotherapy with Methotrexate Followed by Consolidation with Stem Cell Rescue vs. the Same Therapy Without Methotrexate Stewart Goldman, MD
     
  Germ Cell Tumors  
ACNS0122 A Phase II Study to Assess the Ability of Neoadjuvant Chemotherapy +/- Second Look Surgery To Eliminate All Measurable Disease Prior to Radiotherapy For NGGCT Stewart Goldman, MD
ACNS0232 Radiotherapy Alone Vs. Chemotherapy Followed by Response-based Radiotherapy for Newly Diagnosed Primary CNS Germinoma Stewart Goldman, MD
     
  Neurofibromatosis and Malignant Peripheral Nerve Sheath Tumors (MPNST)  
CNS 1007 Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated High Grade Unresectable Malignant Peripheral nerve Sheath Tumors Stewart Goldman, MD
     
  Low-Grade Glioma  
ADVL0515

A Phase I Study of Vinblastine in Combination with Carboplatin for Children with Newly Diagnosed and Recurrent Low-Grade Gliomas

 Stewart Goldman, MD 
     
  Relapsed, Refractory or Progressive Brain Tumors  
ONC 0205 Anti-Angiogenic Chemotherapy: A Phase II Trial of Oral 5-Drug Regimen in Patients with Poor Prognosis, Relapsed or Progressive Cancer Stewart Goldman, MD
CNS 1100 A Phase I Study Using Submyeloablative Dosing of Intravenous Busulfan (Busulfex) for Refractory Brain Tumors Amy Rosenfeld, MD
ADVL0414 A Phase I Study of Temozolomide, Oral Irinotecan and Vincristine for Children with Refractory Solid Tumors Stewart Goldman, MD
ADVL0416 A Phase 1 Study of SAHA in Pediatric Patients with Recurrent or Refractory Solid Tumors (Including Lymphomas) and Leukemia Stewart Goldman, MD
ADVL0517 A Phase I Study of Ispinesib (SB-715992) In Pediatric Patients with Relapsed or Refractory Solid Tumors Stewart Goldman, MD
PBTC-020 A Phase I Clinical Trial of AZD2171 in Children with Recurrent or Progressive Central Nervous System (CNS) Tumors Stewart Goldman, MD
PBTC-023 Phase I and Pharmacokinetic Study of Enzastaurin (LY317615) in Children and Adolescents with Refractory Primary CNS Tumors Stewart Goldman, MD
PBTC-024 A Phase I Study of MK-0752 in Pediatric Patients with Recurrent or Refractory CNS Malignancies Stewart Goldman, MD
     
Relapsed, Refractory or Progressive High-Grade Gliomas (including Brainstem Glioma)  
     
  Relapsed, Refractory or Progressive Low-Grade Glioma  
ADVL0515 A Phase I Study of Vinblastine in Combination with Carboplatin for Children with Newly Diagnosed and Recurrent Low-Grade Gliomas Stewart Goldman, MD
PBTC-022 Phase II Study of Bevacizumab Plus Irinotecan (Captosar) in Children with Recurrent, Progressive, or Refractory Malignant Gliomas and Diffuse / Intrinsic Brain Stem Gliomas, Medulloblastomas and Ependymomas Stewart Goldman, MD
     
  Relapsed, Refractory or Progressive Ependymoma  
PBTC-022 Phase II Study of Bevacizumab Plus Irinotecan (Captosar) in Children with Recurrent, Progressive, or Refractory Malignant Gliomas and Diffuse / Intrinsic Brain Stem Gliomas, Medulloblastomas and Ependymomas Stewart Goldman, MD
     
  Relapsed, Refractory or Progressive Medulloblastoma  
PBTC-022 Phase II Study of Bevacizumab Plus Irinotecan (Captosar) in Children with Recurrent, Progressive, or Refractory Malignant Gliomas and Diffuse / Intrinsic Brain Stem Gliomas, Medulloblastomas and Ependymomas Stewart Goldman, MD
     
  Neoplastic Meningitis  
PBTC-019 A Phase I Pharmacokinetic Optimal Dosing Study of Intrathecal Topotecan for Children with Neoplastic Meningitis Stewart Goldman, MD
     
  Brain Tumor Biology Studies