Marilyn Lamm

 

Marilyn LG Lamm, Ph.D.   
Marilyn_Lamm 

Research Assistant Professor, Developmental Biology Program

mlamm@northwestern.edu  

Children's Memorial Research Center
2300 Children's Plaza #204 Room C421E
Chicago, IL 60614-3394
Phone: (773) 755-6569
Fax: (773) 755-6385

 

Education 
  Year  Degree  Institution 
    B.S. (Zoology) Mindanao State University, Philippines
    Ph.D. (Physiology)    University of Illinois, Champaign-Urbana, IL

 

Research Interests 
  The lab investigates signaling mechanisms between cancer cells and the bone stromal microenvironment that uniquely favor carcinoma metastasis in bone. On-going studies focus on interactions among prostate cancer cells, osteoblasts, and collagen extracellular matrix via the Sonic hedgehog signaling pathway, and how these interactions contribute to the preferential development of prostate carcinoma metastasis in bone. The ultimate goal is to identify specific targets for more effective therapeutic strategies against bone metastasis, the leading cause of mortality among men with advanced prostate cancer.

 

Lab Affiliations 
  Lamm lab 
Research Assistant Professor, Developmental Biology Program     

 

Professional Affiliations 
  American Association for Cancer Research (AACR)
American Association for the Advancement of Science (AAAS)
Minorities in Cancer Research (MICR)
Women in Cancer Research (WICR)
Society for Basic Urologic Research (SBUR)
Northwestern University Bone and Osteoporosis Program (NUBOP)
Robert H. Lurie Comprehensive Cancer Center

 

Scholarly Bibliography (pertinent to current research) 
  A.  Original, Peer-reviewed Research Articles: 
  1. Samantha M Zunich, Taneka Douglas, Maria Valdovinos, Tiffany Chang, Wade Bushman,David Walterhouse, Philip Iannaccone and Marilyn LG Lamm. Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation. Molecular Cancer 8:12-22, 2009.
  2. Fan L, Pepicelli CV, Dibble CC, Catbagan W, Zarycki JL, Laciak R, Gipp J, Shaw A, Lamm MLG, Munoz A, Lipinski R, Thrasher JB, Bushman W: Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology 145:3961-3970, 2004.
  3. Walterhouse DO, Lamm MLG, Villavicencio E, Iannaccone P: Emerging roles for hedgehog-Patched-Gli signal transduction in reproduction. Biology of Reproduction 69: 8-14, 2003.
  4. Lamm MLG, Catbagan WS, Laciak RJ, Barnett DH, Hebner CM, Gaffield W, Walterhouse D, Iannaccone P, Bushman W: Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Developmental Biology 249: 349-366, 2002.
  5. Lamm MLG, Podlasek CA, Barnett DH, Lee J, Clemens JQ, Hebner CM, Bushman W: Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate. Developmental Biology 232: 301-314, 2001.
  6. Sintich SM, Lamm MLG, Sensibar JA, Lee C: Transforming growth factor-β1 induced proliferation of the prostate cancer cell line, TSU-Pr1: the role of platelet-derived growth factor. Endocrinology 140: 3411-3415, 1999.
  7. Lamm MLG, Sintich SM, Lee C: A proliferative effect of transforming growth factor-β1 on a human prostate cancer cell line, TSU-Pr1. Endocrinology 139: 787-790, 1998.
  8. Lamm MLG, Long DD, Goodwin SM, Lee C: Transforming growth factor-β1 inhibits membrane association of protein kinase Cα in a human prostate cancer cell line, PC3. Endocrinology 138:657-4664, 1997.
     
  B.  Reviews and Book Chapters: 
  1. Iannaccone P, Holmgren R, Lamm MLG, Ahlgren S, Lakiza O, Yoon JW, Walterhouse D: The Sonic Hedgehog Signaling Pathway. In “Inborn Errors in Development: The Molecular Basis of Clinical Disorders of Morphogenesis” (Epstein CJ et al., eds). Oxford Monographs on Medical Genetics, Second Edition, 2008.
  2. Lamm MLG and Bushman W: Hedgehog signalling in prostate morphogenesis. In “Shh and Gli Signalling and Development” (Howie S and Fisher C, eds) Landes Bioscience, 2007.

 

 Professional Service 

  2004-2005 Member, Scientific Merit Peer Review Panel, Prostate Cancer Research Program, Congressionally Directed Medical Research Program (CDMRP), Department of Defense
  2004 Member, Special Emphasis Panel, National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK), National Institutes of Health (NIH)
  2006-2008 Ad Hoc Member, Scientific Initial Review Group, Subcommittee I - Career Development, National Cancer Institute
  2007               Chair, Peer Review, Mock Study Section, Mentored Career Development Award, Comprehensive Minority Biomedical Branch, National Cancer Institute
  2007- Manuscript Reviewer: American Journal of Pathology, Journal of Cellular Biochemistry, Molecular and Cellular Biology, Clinical and Experimental Medicine
  2007-2010   Chair, Distinguished Lecturer Seminar Series Committee, CMRC
  2008-2011 Regular Member, Scientific Initial Review Group, Subcommittee I - Career Development, National Cancer Institute
  2009 Ad Hoc Member, Scientific Review Group, ARRA, GO Molecular Target Discovery and Development Centers Pilot Program, National Cancer Institute
  2010 Member, Judging Committee, Biomedical Research Symposium, CMRC
  2010 - Vice-Chair, Institutional Animal Care and Use Committee, CMRC
  2011 Cancer Scientist Member, Illinois Delegation, American Cancer Society Cancer Action Network, Leadership Summit and Lobby Day

 

Websites 
  Robert H. Lurie Comprehensive Cancer Center