Children's Memorial Hospital / Department of Pathology and Laboratory Medicine / Pathology Research 

Pathology and Laboratory Medicine Research

		Faculty  Elizabeth Perlman, MD, Arthur C. King Professor of Pathology and Laboratory Medicine  Maurice O'Gorman, PhD  Katrin Carlson Leuer, PhD Pauline Chou, MD  Michael Kevin Fritsch, MD, PhD Vasil Galat, PhD Lawrence Jennings, MD, PhD   Hector Melin-Aldana, MD  Maria Proytcheva, MD  Veena Rajaram, MD  Glenn Ramsey, MD Frederick Smith, MD  Xiaotian Zheng, MD, PhD
From: Hulspas R, O'Gorman MR, Wood BL, Gratama JW, Sutherland DR. Considerations for the control of background fluorescence in clinical flow cytometry. Cytometry B Clin Cytom2009 Nov;76(6):355-64.

 The department actively participates in the research effort of Children’s Memorial Medical Services in the following ways:

• Provision of core facilities and services: The Division of Anatomic Pathology services include the gross and microscopic examination of surgical specimens, histology, immunohistochemistry, molecular diagnostics, electron microscopy, cytopathology and post-mortem studies. The Research Histology facility provides high quality research histology, sections from frozen and paraffin-embedded tissues, routine hematoxylin and eosin stained slides, and special stains and immunohistochemistry. This core facility of the research center is led by Samantha Gadd. 
• Provision of cutting edge technology: The Diagnostic Immunology Laboratory offers state-of-the-art local and outreach laboratory services for clinicians and investigators involved in the diagnosis, monitoring and evaluation of pediatric immunodeficiency, autoimmune and allergic diseases. 
• Collaborative research: A large part of the department’s mission is to contribute the specialized expertise of those in clinical and anatomic pathology to research across the institution. Of note this year were a series of studies on the PHOX2B gene by Lawrence Jennings and the Center for Autonomic Medicine (CAMP). PHOX2B mutations result in congenital central hypoventilation syndrome (CCHS), which usually presents in the newborn period and may be life-threatening without prompt diagnosis and intervention. The studies were aimed at refining the test for CCHS in order to improve diagnostics. 
• Independent research: Studies in the laboratory of Elizabeth Perlman are aimed at defining biological markers that shed light on the pathogenesis and/or aid in the therapeutic stratification of pediatric renal tumors and pediatric sarcomas in collaboration with the Children’s Oncology Group (COG). Vasil Galat focuses on the differentiation lineages and utilization of stem cells in the study of human disease. 

Websites include:

Children's Memorial Hospital Department of Pathology and Laboratory Medicine

Northwestern University Feinberg School of Medicine Department of Pathology