Simone Treiger Sredni, MD, PhD 

Research Assistant Professor
Department of Pediatrics
Northwestern University Feinberg School of Medicine
Center of Excellence in Clinical Immunology
Neurosurgery Research Program
Children's Memorial Research Center

ssredni@childrensmemorial.org
2300 Children's Plaza, Box 212
Chicago, IL 60614-3363
Phone: (773) 755-6572 ext 4 (within CMH/CMRC ext 57309)
Fax: (773) 755-6374

Simone Sredni, MD, PhD 

Curriculum Vitae  

Training:  

  • M.D degree: Faculdade de CiênciasMédicas da Santa Casa de São Paulo – São Paulo, Brazil - 1990  
  • Pathology residency: Faculdade de Medicina da Universidade Estadual de Campinas – UNICAMP (University of Campinas Medical School), Campinas, Brazil – 1991-1992  
  • Pathology residency: Faculdade de Medicina da Unversidade de São Paulo – USP (São Paulo’s University Medical School ), São Paulo, Brazil – 1992-1994  
  • PhD degree: Faculdade de Medicina da Unversidade de São Paulo – USP (São Paulo’s University Medical School ), São Paulo, Brazil – 1999  
  • Postdoctoral Training: Ludwig Institute for Cancer Research – São Paulo, Brazil – 2002-2004  


Expertise:  

Diagnosis and Biology of Pediatric Solid TumorsI am currently involved in the study of Childhood Tumors of the Kidney and of the Central Nervous System with special interest in the epigenetic mechanisms of regulation of the aggressive behavior of the Malignant Rhabdoid Tumors. My purpose is to better understand the biology of these rare tumors and to uncover novel targets for future therapy development. The fact that 70% of children with Malignant Rhabdoid Tumors present with non-localized disease at the time of the diagnosis and a relapse free survival of only 10 months illustrate the extraordinary aggressiveness of this type of tumor. An enormous concern is the absence of a nationwide treatment protocol for patients with these tumors. The currently treatment involves empirically selected combinations of highly toxic chemotherapeutic agents to which tumors rarely respond.

Epigenetic Mechanisms of Regulation of Gene ExpressionMy efforts in better understanding the biology of pediatric embryonal tumors include the search for the main processes, molecular networks and signaling pathways involved in the different aspects of these entities using high throughput protein-coding genes and miRNAs expression profiling. The expertise acquired in these studies has brought me several opportunities of collaboration. The most exciting of them involves the study of miRNA expression in muscle of children with Juveniel Dermatomyositis (JDM) with Dr. Lauren M. Pachman.