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Topczewski Laboratory


 

Lab2011 

The Topczewski laboratory investigates the mechanisms that control the morphogenetic processes of vertebrate embryos, by using zebrafish as a model. Similarities in developmental programs among all vertebrates make zebrafish an excellent model for studying human diseases and development. In our work we utilize a combination of genetic analysis with embryological and molecular methods uniquely available in zebrafish. Our long-term goal is the identification of signaling pathways that will suggest novel candidate genes involved in human congenital abnormalities and diseases. 


Recent Publications

Dale RM, Topczewski J. (June 2011) Identification of an evolutionarily conserved regulatory element of the zebrafish col2a1a gene. Dev Bio 357;518-531

Duszynski RJ, Topczewski J, LeClair EE. (2011) Simple, Economical Heat-Shock Devices for Zebrafish Housing Racks. Zebrafish in press 

 

Sarmah S, Barrallo-Gimeno A, Melville DB, Topczewski J, Solnica-Krezel L, Knapik EW. (2010) Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis.  PLoS One. 28;5:e10367.
 

LeClair EE, Topczewski J, (2010) Development and Regeneration of the Zebrafish Maxillary Barbel: A Novel Study System for Vertebrate Tissue Growth and Repair.  PLoS ONE 5: e8737.
 

Camarata T, Krcmery J, Snyder D, Park S, Topczewski J, Simon H-G (2010). Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation.  Dev Biol 15;337:233-345. Epub 2009 Nov 3 

LeClair EE, Topczewski J (2009) Methods for the study of the zebrafish maxillary barbel.  JoVE 23;(33). pii: 1558.

Topczewski J and Solnica-Krezel L. (2009). Cytoskeletal dynamics of the zebrafish embryo. Essential zebrafish methods: Cell and developmental biology. Reliable Lab Solutions Series. Elsevier Inc. pp 133-157

LeClair EE, Mui S, Huang A, Topczewska JM, Topczewski J (2009) Craniofacial skeletal defects of adult zebrafish glypican 4 (knypek) mutants.  Dev Dynamics 238(10):2550-2563 

Sisson BE and Topczewski J (2009). Expression of five frizzleds during zebrafish craniofacial development.  GEP: 520-7 

Drerup CM, Wiora HM, Topczewski J, Morris JA. (2009). Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation.  Development: 136(15): 2623-2632

Dale RM, Sisson BE, Topczewski J. (2009). The Emerging Role of Wnt/PCP Signaling in Organ Formation.  Zebrafish 6:9-14

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