Topczewski Laboratory

Recent Awards

  • Dr. Rodney M. Dale, Postdoctoral Associate won Kirschstein National Research Service Award from NIH/NIDCR.
  • Jorge Cantu, graduate student in the NUIN program,  has been selected as trainee for the Cellular and Molecular Basis of Disease Training Program at Northwestern University.

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The Topczewski laboratory investigates the mechanisms that control the morphogenetic processes of vertebrate embryos, by using zebrafish as a model. Similarities in developmental programs among all vertebrates make zebrafish an excellent model for studying human diseases and development. In our work we utilize a combination of genetic analysis with embryological and molecular methods uniquely available in zebrafish. Our long-term goal is the identification of signaling pathways that will suggest novel candidate genes involved in human congenital abnormalities and diseases.
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Recent Publications

LeClair EE, Topczewski J, (January 2010) Development and Regeneration of the Zebrafish Maxillary Barbel: A Novel Study System for Vertebrate Tissue Growth and Repair.  PLoS ONE 5(1): e8737. doi:10.1371/journal.pone.0008737

Leclair EE, Topczewski J (November 2009) Methods for the study of the zebrafish maxillary barbel.  JoVE 23;(33). pii: 1558. doi: 10.3791/1558.

Camarata T, Krcmery J, Snyder D, Park S, Topczewski J, Simon H-G (November 2009). Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation.  Developmental Biology [Epub ahead of print]

Topczewski J and Solnica-Krezel L. (September 2009). Cytoskeletal dynamics of the zebrafish embryo. Essential zebrafish methods: Cell and developmental biology. Reliable Lab Solutions Series. Elsevier Inc. pp 133-157

LeClair EE, Mui S, Huang A, Topczewska JM, Topczewski J (September 2009) Craniofacial skeletal defects of adult zebrafish glypican 4 (knypek) mutants.  Dev Dynamics 238(10):2550-2563

Sisson BE and Topczewski J (October 2009). Expression of five frizzleds during zebrafish craniofacial development.  GEP: 520-7

Drerup CM, Wiora HM, Topczewski J, Morris JA. (August, 2009). Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development: 136(15): 2623-2632

Dale RM, Sisson BE, Topczewski J. (March, 2009). The Emerging Role of Wnt/PCP Signaling in Organ Formation.  Zebrafish:  6:9-14


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