Jacek Topczewski, Ph.D.

Assistant Professor of Pediatrics

jacek_profile

Northwestern University, Feinberg School of Medicine,

Children's Memorial  Research Center

Developmental Biology Program

j-topczewski@northwestern.edu

2300 Children's Plaza
Box 204 Room C.421F
Chicago, IL 60614
Phone: (773) 755-6545
Fax: (773) 755-6385

 

Education
  Year Degree Institution
  1996 Ph.D. Institute of Biochemistry and Biophysics, Polish Academy of Science
  1988 M.Sc. University of Warsaw

 

Research Interests
 
  • Role of Wnt signaling in zebrafish cartilage morphogenesis.
  • Function of Glypicans (heparan sulfate proteoglycans) in zebrafish development.

 

Research Funding
  Title Funding Source Period
  WNT SIGNALING IN CRANIOFACIAL CARTILAGE MORPHOGENESIS NIH/NIDCR 2006 - 2011

 

Lab Affiliations
  Topczewski lab

 

 

Recent Publications
 

Sarmah S, Barrallo-Gimeno A, Melville DB, Topczewski J, Solnica-Krezel L, Knapik EW. (April 2010) Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. PLoS One. 2010 Apr 28;5(4):e10367.

LeClair EE, Topczewski J, (January 2010) Development and Regeneration of the Zebrafish Maxillary Barbel: A Novel Study System for Vertebrate Tissue Growth and Repair.  PLoS ONE 5(1): e8737. doi:10.1371/journal.pone.0008737

Leclair EE, Topczewski J (November 2009) Methods for the study of the zebrafish maxillary barbel.  JoVE 23;(33). pii: 1558. doi: 10.3791/1558.

Camarata T, Krcmery J, Snyder D, Park S, Topczewski J, Simon H-G (November 2009). Pdlim7 (LMP4) regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation.  Developmental Biology [Epub ahead of print]

Topczewski J and Solnica-Krezel L. (September 2009). Cytoskeletal dynamics of the zebrafish embryo. Essential zebrafish methods: Cell and developmental biology. Reliable Lab Solutions series. Elsevier Inc. pp 133-157

LeClair EE, Mui S, Huang A, Topczewska JM, Topczewski J (September 2009) Craniofacial skeletal defects of adult zebrafish glypican 4 (knypek) mutants.  Dev Dynamics 238(10):2550-2563

Sisson BE and Topczewski J (October 2009). Expression of five frizzleds during zebrafish craniofacial development.  GEP: 520-7

Drerup CM, Wiora HM, Topczewski J, Morris JA. (August, 2009). Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development: 136(15): 2623-2632

Dale RM, Sisson BE, Topczewski J. (March, 2009). The Emerging Role of Wnt/PCP Signaling in Organ Formation.  Zebrafish 6:9-14

Postel R, Vakeel P, Topczewski J, Knöll R, Bakkers J. (June, 2008). Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Developmental Biology: 92-101.

Carney TJ, von der Hardt S, Sonntag C, Amsterdam A, Topczewski J, Hopkins N, Hammerschmidt M. (October, 2007). Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development: 3461-3271.

Inbal A, Topczewski J, Solnica-Krezel L (November, 2006). Targeted gene expression in the zebrafish prechordal plate. Genesis: 584-588.

Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, Nickoloff BJ, Topczewski J and Hendrix MJC (August, 2006). Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness . Nat Med: 925 - 932.

Lin F, Sepich DS, Chen S, Topczewski J, Yin C, Solnica-Krezel L, Hamm H. (June, 2005). Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. J Cell Biol: 777-787.

Cooper MS, Szeto DP, Sommers-Herivel G, Topczewski J, Solnica-Krezel L, Kang HC, Johnson I, Kimelman D. (February, 2005). Visualizing morphogenesis in transgenic zebrafish embryos using BODIPY TR methyl ester dye as a vital counterstain for GFP.. Dev Dyn: 359-368.

Ninkovic J, Tallafuss A, Leucht C, Topczewski J, Tannhauser B, Solnica-Krezel L, Bally-Cuif L (January, 2005). Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development: 75-88.

Topczewska JM, Topczewski J, Shostak A, Solnica-Krezel L, and Hogan BLM (May, 2003). Developmentally regulated expression of two members of the Nrap family in zebrafish. Gene Expr Patterns: 169-171.

Jessen JR, Topczewski J, Bingham S, Sepich DS, Marlow F, Chandrasekhar A, Solnica-Krezel L (August, 2002). Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements.. Nat Cell Biol.: 610-615.

Marlow F, Topczewski J, Sepich D, Solnica-Krezel L (June, 2002). Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr Biol: 876-884.

Topczewska JM, Topczewski J, Shostak A, Kume T, Solnica-Krezel L, Hogan BL (September, 2001). The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. Genes Dev: 2483-2493.

Topczewski J, Sepich DS, Myers DC, Walker C, Amores A, Lele Z, Hammerschmidt M, Postlethwait J, Solnica-Krezel L (August, 2001). The zebrafish glypican knypek controls cell polarity during gastrulation movements of convergent extension. Dev Cell: 251-264.



View Publications by Jacek Topczewski  listed in the National Library of Medicine (PubMed)

 

Professional Service
  2005 - Present Member, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine

 

Websites
  Integrated Graduate Program (IGP) 
Northwestern University Institute for Neuroscience (NUIN) 
Topczewski Laboratory
Zebrafish Information Network

 

Advising
  Member of Trustee Committee with Sciencific Board of Institute of Biochemistry and Biophysics, Polish Academy of Science