Why use zebrafish as a model?

Genetic accessibility

• Small, cheaply maintained
• Lay hundreds of eggs at weekly intervals
• Short generation time 2-3 months
• Easy to perform large scale forward-genetic analysis

Experimental accessibility

• Externally fertilized
• Accessible to observation and manipulation from the moment of fertilization
• Manipulation of gene activity by oligonucledide, RNA and DNA injection
• Generation of transgenic animals

Optical transparency

• Fate mapping
• Fluorescent tracer time-lapse lineage analysis
• Single cell transplantation

To learn more about research using zebrafish go to:
The Zebrafish Information Network