Adeno-associated viruses (AAV) are non-pathogenic human single strand DNA parvoviruses. AAV vectors are devoid of viral genes and can hold up to a 4.5kb expression cassette between the inverted terminal repeats (ITRs). Recent advances in technology for packaging AAV in the absence of helper virus permits these vectors to be produced at high titers of 10^12-14 vector genomes/ml. AAV viruses are able to infect dividing and non-dividing cells and are excellent for in vivo studies. The vector core offers serotype 2 and will offer other serotypes in the future.

Download a printable rAAV vector request form

LV vectors belong to the family retrovirae. The most commonly used lentivirus for gene delivery is based HIV-1. LV vectors have a cloning capacity of 6-7kb. Vectors are pseudotyped with the vesicular stomatitis virus glycoprotein (VSV-G) to broaden cellular tropism. VSV-G LV vectors are particularly useful for infecting non-dividing neurons and have a high tropism for stem cells and other cultured cells. Lentiviruses also are useful for generating transgenic rats and for RNAi studies. Vectors produced by the core have a titer of 10^8-9 transducing units/ml and are helper virus free.

Download a printable Lentiviral vector request form.